home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410o.zip
/
M94A2860.TXT
< prev
next >
Wrap
Text File
|
1994-10-25
|
2KB
|
40 lines
Document 2860
DOCN M94A2860
TI Study of 31 acute HIV-1 infection (API).
DT 9412
AU Sinicco A; Biglino A; Gioannini P; Inst. Infect. Diseases, Univ. of
Turin, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):208 (abstract no. PB0262). Unique
Identifier : AIDSLINE ICA10/94369715
AB We directly observed 31 API and 168 asymptomatic seroconversions (AS) in
patients (pts) who were seronegative in the previous 12 months. API was
more frequently seen in pts who had HIV-1 through sex (chi 2 = 29.1; p =
.00000). Api clinical aspects ranged from flu-like syndrome to
mononucleosis-like syndrome. Two pts had a polyneuropathy and 2 a
meningitis. At onset, all the pts were anti-HIV-1Ab (ELISA) negative and
27/32 had serum p24Ag. Serum p24Ag was found after immune complex
dissociation in the other pts. CD4+/CD8+ ratio was low in most pts
because of CD8+ increase, whereas CD4+ were slightly low. NK were also
increased. Seroconversion with ELISA occurred in a mean time of 41.7 +/-
15.3 days. HIV-1 with rapid-high syncytium inducing phenotype was
isolated in 4/7 pts. At the onset, in 15 pts IL-2 serum levels was low,
soluble CD8 antigen, IL-1 beta, IFN-gamma and 5'-neopterin were
increased. Follow-up showed significant decrease of IL-1 beta levels and
increase of IL-6. API pts resulted significantly at higher risk of
developing AIDS than AS (43% vs 7% at 45 months; p = .00001). On the
basis of our results the early administration of antiviral drugs and
IL-2 is of interest.
DE Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY Antigens, CD8/ANALYSIS
AIDS-Related Complex/BLOOD/COMPLICATIONS/*EPIDEMIOLOGY/
MICROBIOLOGY/TRANSMISSION Biopterin/ANALOGS & DERIVATIVES/BLOOD
Comparative Study Cytopathogenic Effect, Viral Enzyme-Linked
Immunosorbent Assay Human HIV Antibodies/BIOSYNTHESIS HIV
Seropositivity *HIV-1/ISOLATION & PURIF Interferon Type II/BLOOD
Interleukin-1/BLOOD Interleukin-2/BLOOD/DEFICIENCY Meningitis/ETIOLOGY
Peripheral Nervous System Diseases/ETIOLOGY Phenotype Prospective
Studies Risk Factors Sex Behavior MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).